The quick answer is, Yes. The modifications you are planning, especially the Vortec heads, will require a custom Tuned Chip.

Most members here, including myself, use TunerPro RT software to custom tune a TBI chip.

When I custom tune a TBI chip, I first modify the timing tables and fuel tables. The fuel and spark changes in the chip are based on my personal experience from engines with similar type modifications. The next step is to record data logs (sometimes several), and make the necessary changes to the chip for spark knock and rich / lean fuel conditions identified in the data log.

The "Ultimate" TBI modification is a custom tuned chip!

dave w